The human cathelicidin antimicrobial peptide, studied for immune defense and wound healing.
01Overview
LL-37 is the only human cathelicidin-derived antimicrobial peptide, a 37-residue chain (beginning with two leucines) produced by immune and epithelial cells as part of innate immunity.
Research spans direct antimicrobial action, immune modulation, and tissue-repair signaling.
02Mechanism
- Disrupts microbial membranes through its amphipathic, cationic structure.
- Modulates immune-cell recruitment and inflammatory signaling.
- Promotes angiogenesis and re-epithelialization in wound models.
03Research uses
- Innate-immunity and antimicrobial research
- Wound-healing and re-epithelialization models
- Inflammation and biofilm studies
04Key findings
- Broad activity against bacteria, some fungi, and enveloped viruses in vitro.
- Dual role: antimicrobial at some concentrations, immunomodulatory at others.
- Dysregulation is studied in inflammatory skin conditions.
05Handling & reconstitution
- Supplied lyophilized; relatively sensitive to handling.
- Reconstitute with bacteriostatic water; swirl gently and avoid foaming.
- Store frozen when lyophilized; keep reconstituted solution cold and use promptly.
Research use only
All information on peptek is aggregated from public sources for research and educational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease. Peptide products referenced here are not for human consumption of any kind. Always consult a qualified healthcare professional before beginning any research protocol.