The three-residue tail of alpha-MSH, studied as a focused anti-inflammatory signal.
01Overview
KPV is the C-terminal tripeptide (lysine-proline-valine) of alpha-melanocyte-stimulating hormone. It retains much of the parent hormone’s anti-inflammatory activity without its pigmentary effects.
It is investigated for gut and skin inflammation and immune modulation.
02Mechanism
- Enters cells and interferes with NF-κB signaling, a master switch for inflammation.
- Reduces production of pro-inflammatory cytokines.
- Exhibits antimicrobial activity in some models.
03Research uses
- Inflammatory-bowel and mucosal-integrity research
- Skin-inflammation models
- Immune-modulation studies
04Key findings
- Reduces intestinal inflammation markers in colitis models.
- Frequently paired with BPC-157 in gut-repair research contexts.
- Small size supports oral and topical experimental delivery.
05Handling & reconstitution
- Supplied lyophilized as a white powder.
- Reconstitute with bacteriostatic water; swirl gently.
- Store cold; keep reconstituted solution refrigerated and dark.
Research use only
All information on peptek is aggregated from public sources for research and educational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease. Peptide products referenced here are not for human consumption of any kind. Always consult a qualified healthcare professional before beginning any research protocol.