BPC-157

A stable 15-residue partial sequence of a gastric protein, studied broadly for tissue repair and gut health.

01Overview

BPC-157 is a synthetic peptide based on a fragment of a protective protein found in gastric juice. It is notably stable in acidic and aqueous conditions, which underlies much of the research interest.

Its regulatory status has shifted recently: it was removed from the FDA’s bulk-substances Category 2 list in April 2026 and is under continued review, so status should be verified against current guidance.

02Mechanism

• Promotes angiogenesis — the formation of new blood vessels supporting healing.
• Interacts with the nitric oxide (NO) system and growth-factor pathways involved in tissue remodeling.
• Supports the integrity of the gut lining and tendon/ligament fibroblast activity in models.

03Research uses

• Musculoskeletal-repair research (tendon, ligament, muscle)
• Gastrointestinal-integrity models
• Angiogenesis and wound-healing studies

04Key findings

• Animal studies report accelerated tendon-to-bone and muscle healing.
• Protective effects on the gastrointestinal mucosa are among the most-replicated findings.
• Human clinical evidence remains limited; most data are preclinical.

05Handling & reconstitution

• Supplied lyophilized; unusually stable relative to many peptides.
• Reconstitute with bacteriostatic water; swirl gently.
• Store lyophilized cold; reconstituted solution keeps refrigerated for a limited window.